Keratinocytes are the predominant cell type (approximately 90%) in the epidermis, the outermost layer of the skin. Keratinocytes primary function is the formation of a barrier against environmental damage. Once pathogens start to invade the upper layers of the epidermis, keratinocytes can react by producing proinflammatory mediators, which attract leukocytes to the site of invasion. Structural proteins, enzymes, lipids and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinization is part of the physical barrier formation, in which the keratinocytes produce more and more keratin and undergo terminal differentiation. The fully cornified keratinocytes that form the outermost layer are constantly shed off and replaced by new cells. At each stage of differentiation, keratinocytes express specific Keratins (Keratin 10; Keratin 14). Many different factors promote keratinocyte differentiation: calcium gradients, Vitamin D3, … to name but a few.
Within the epidermis keratinocytes are associated with other cell types such as Melanocytes. Keratinocytes also modulate the immune systems and are potent producers of anti-inflammatory mediators (e.g. IL-10, TGF-ß). When activated, Keratinocytes stimulate cutaneous inflammation. Skin damage is partially repaired via the migration of Keratinocytes to fill in the gap created by the wound.
20, impasse des Sources
|CM-1001-111||Cryoconserved Human Epidermal Keratinocytes (HEK) (>500,000 cells), adult (Abdominal; Breast; Facial skin)||Culture Media CM-3001-042, CM-3001-045||382.50 €|
|CM-1001-181||Proliferating Human Epidermal Keratinocytes (HEK) (2* T75 flaks), adult (Abdominal, Breast, Facial skin), with Ca++||Culture Media CM-3001-042||450.00 €|
|CM-1001-182||Proliferating Human Epidermal Keratinocytes (HEK) (2* T75 flaks), adult (Abdominal, Breast, Facial skin), Ca++ free||Culture Media CM-3001-045||450.00 €|