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Blood (Peripheral) Cells

The average human adult has more than 5 liters of blood in his body. Blood carries oxygen and nutrients to living cells and takes away their waste products. It delivers immune cells to fight infections and contains platelets that can form a plug in a damaged blood vessel to prevent blood loss. Through the circulatory system, blood adapts to the body's needs. When you are exercising, your heart pumps harder and faster to provide more blood and hence oxygen to your muscles. During an infection, the blood delivers more immune cells to the site of infection, where they accumulate to ward off harmful invaders.

White Blood Cells are part of the Immune Response and exist in many different shapes and sizes. One of the most important populations of white blood cells have one large, round nucleus: Mononuclear Cells.

Despite their differences in appearance, all of the various types of White Blood Cells have a role in the immune response. They circulate in the blood until they receive a signal that a part of the body is damaged. Signals include pro- and anti-inflammatory cytokines, molecules secreted by macrophages that contribute to the fever of infections, and histamine, which is released by circulating basophils and tissue mast cells and contributes to allergic reactions. In response to these signals, the White Blood Cells leave the blood vessel by squeezing through holes in the vascular wall. They migrate to the source of the signal and help begin the healing process.

Individuals who have low levels of White Blood Cells may have more and worse infections. Depending upon which White Blood Cells are missing, the patient is at risk for different types of infection. For example, macrophages are especially good at digesting bacteria, and a deficiency in macrophages leads to recurrent bacterial infections. In contrast, T-cells are particularly skilled in fighting viral infections, and a loss of their function results in an increased susceptibility to viral infections.

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CM-1050-211 Differentiated Functionally Characterised Human Macrophages (2* T75 flasks), adult 0.00 €