Efficacy and toxicity

The use of plant-derived bioactive compounds has gained significant popularity due to their potential benefits such as weight loss, stress relief, and revitalization. However, despite their seemingly harmless nature, these products may carry hidden health risks. As the global focus shifts towards dietary supplements, their effectiveness and health-promoting properties are often attributed to their antioxidant, anti-inflammatory, and anti-proliferative properties. To ensure their optimal effectiveness, it is necessary to extract and concentrate bioactive compounds using advanced technological processes that allow them to reach the desired plasma concentrations.

Considering the highly concentrated nature of these compounds, it is crucial to assess their efficacy, quality, and potential toxicity in order to safeguard human health. One solution lies in utilizing human primary cell models, which accurately reflect human biology and surpass the limitations of cell lines. By subjecting these models to rigorous assessments, employing functional classifiers, and analyzing gene expression, we can obtain a comprehensive understanding of the effects of novel bioactive compounds. Additionally, mass spectrometry plays a critical role in providing insights into compound distribution and metabolism. This integrated approach, supported by a robust dataset, expedites the discovery and development of safe and effective bioactive compounds.