TLR Agonists
Validate your MAT system with CellMade™ high-purity agonists. Our Ph. Eur. 2.6.30 compliant reference molecules ensure precise detection of endotoxins and NEPs across TLR2, TLR4, and TLR7/8 for full regulatory alignment.
CellMade™ provides a comprehensive ecosystem for the Monocyte Activation Test (MAT), offering high-purity characterized agonists designed to validate the detection of both endotoxins and Non-Endotoxin Pyrogens (NEPs) in accordance with Ph. Eur. 2.6.30. By providing specific reference molecules for surface receptors like TLR4 and TLR2, as well as endosomal receptors like TLR7/8 and TLR9, CellMade™ ensures that laboratories can accurately mimic the human innate immune response and monitor pro-inflammatory cytokine cascades (IL-6, IL-1β, TNF-α). With nearly two decades of expertise, our solutions are engineered to meet the latest EDQM mandates for the mandatory replacement of animal-based testing, delivering unrivaled reliability with R2 values > 0.975 in validation curves. This specialized portfolio is supported by a restricted purchase license and a mandatory technical onboarding process—including method development and on-site training—to ensure seamless regulatory integration and peak analytical performance.
