Functionally characterized hPBMC

Advance your pyrogen and cytokine release syndrome (CRS) assays with our premium, cryopreserved human Peripheral Blood Mononuclear Cells (PBMCs). Sourced from fully consented, healthy donors under strict IRB-approved protocols, our PBMCs provide a reliable and ethically sound solution for your critical immuno-safety and lot-release testing.

Each vial is guaranteed to contain a minimum of 5 million viable cells, cryopreserved using an optimized process to ensure high post-thaw viability and robust functional performance.

Product Formats for Your Assay Needs

We offer flexible formats designed for the specific demands of pyrogen and CRS testing:

• Single Donor Vials: Ideal for assessing donor-to-donor variability in immune response, a critical factor in both pyrogen sensitivity and CRS risk assessment.
• 4-Donor Pooled Vials: Provides a standardized, representative cell population by averaging individual donor responses. This format is the industry standard for robust, reproducible lot-release testing, such as the Monocyte Activation Test (MAT).

Guaranteed Functional Characterization

Move beyond basic cell counts and viability. Our PBMC lots are rigorously tested for the functional performance required by a pyrogen or CRS assay, providing you with the assurance that your cells are ready for immediate use.

Characterization data includes:

• TLR-Receptor Activation: Our PBMCs are confirmed to be highly responsive to key TLR agonists (e.g., LPS for TLR4, R848 for TLR7/8), demonstrating their suitability for detecting a wide range of pyrogenic contaminants.
• Cytokine Release Profile: Each lot is tested for a strong, low-background cytokine response. We provide specific data on key pyrogen and CRS markers, including IL-6 and TNF-alpha, ensuring a high signal-to-noise ratio and reliable assay performance.

All cells ship with a comprehensive Certificate of Analysis detailing viability, cell count, serology testing, and lot-specific functional data. Ensure the consistency and reliability of your immuno-safety assays with our validated PBMCs.