Low-Volume In Vitro Bio-Functionality & Safety

CellMade replaces resource-intensive legacy assays with high-throughput microscale biological and enzymatic simulations that bridge the gap between benchtop discovery and physiological reality. Designed specifically for precious or limited-yield novel ingredients, our in vitro platform evaluates digestibility, allergenicity, bioavailability, and microbiome stability using a fraction of traditional sample volumes. By combining INFOGEST-aligned gastrointestinal modeling with advanced cellular and transcriptomic readouts, we deliver the mechanistic safety data and nutritional efficacy profiles required to satisfy rigorous EFSA requirements and substantiate high-value commercial claims.

• Automated Microscale Digestibility: Low-volume, INFOGEST-aligned gastrointestinal simulations that quantify protein breakdown dynamics, peptide release, and accurate protein quality metrics (DIAAS/PDCAAS).

• In Vitro Allergenicity & Toxicity: Multiplex ELISA screening and high-resolution transcriptomic profiling to assess IgE-binding potential, structural resistance to digestion, and cellular cytotoxicity.

• Bioavailability & Nutrient Uptake: Human intestinal cell-line transport models (e.g., Caco-2) engineered to evaluate mucosal permeability, active transport, and the systemic absorption of bioactive molecules.

• Microbiome & Fermentation Stability: High-throughput, small-scale batch culture simulations to analyze gut microbiota modulation, short-chain fatty acid (SCFA) production, and metabolic stability.