Innovative diagnosticsand therapeuticsfor metabolic disease

Models of Inflammation

Validated LPS-induced Models of Inflammation

BIOMARKER SOLUTION CENTER: Models

 

Monolayer Inflammatory Models

PBMC, CD14+, Macrophages

  • Functionally characterized: hPBMC are tested for reactivity after cellular stimuli: LPS stimuli followed by TNF-α secretion profile measured in time-response/dose-response manner via Cytometry methods.
  • Functionally characterized: CD14+ are tested for reactivity after cellular stimuli: LPS stimuli followed by TNF-α secretion profile measured in time-response/dose-response manner via Cytometry methods.
  • Functionally characterized: Macrophages are tested for phagocytosis activity

Coculture Models of Inflammation

PBMC – HAoEC; PBMC – HAd; PBMC – HEP

CellMade Advanced Cell Models models are coculture systems that allow cross-talk between two different cell types without any contact between them. These cell culture systems provide a reliable way to identify the earliest biochemical lipid biomarkers of TNF-α activation in real time, right from the very first initiation of inflammatory response. As a result, CellMade Advanced Cell Models models offer the opportunity to identify early biomarkers of inflammation which may be useful to predicting inflammatory response way ahead of cell phenotypic changes or clinical symptoms. The biomarkers discovered using this approach have the added advantage of possessing future feasibility in the clinical setting, since lipids can be readily measured from peripheral samples such as blood.

For further information on our inflammation models and services, please refer to the Documents Centre of this page.

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CellMade Laboratoire

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