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Models of Cardiovascular Disease

BIOMARKER SOLUTION CENTER: Models

 

Monolayer Cardiovascular Models

HAoEC, HAoSMC

  • Functionally characterized: HAoEC are tested for reactivity after cellular stimuli: VEGF for activation of VEGFR and TNF-α for secretion of PGE-2, measured in time-response/dose-response manner via ELISA methods.
  • Functionally characterized: HAoSMC are tested for reactivity after cellular stimuli: TNF-α for activation of PGE-2 secretion, measured in time-response/dose-response manner via ELISA methods.

 

3D Cardiovascular Models

Short-term HAoEC – HAoSMC; Long-term HAoEC – HAoSMC

CellMade advanced 3D cell models using human-origin primary cells are developed for a large variety of applications to study different disease patterns. These models can consist of one or more type of cells. In the current set-up, the advanced models are analyzed in a high content manner via coupling capillary cytometry with LC/MS methods. A 3D model for neo-vascularization comprising Human Aorta Smooth Muscle Cells (HAoSMC) and Human Aorta Endothelial Cells (HAoEC) was developed. This model is useful for studying mechanisms involved in the vascularization process and to screen for angiogenetic properties of drug compounds.

For further information on our cardiovascular models and services, please refer to the Documents Centre of this page.

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