Injury Sensing Assays

BIOMARKER SOLUTION CENTER: Cell-Injury

CellMade developed a comprehensive range of cell-based assays to determine the degree of cell-injury induced using reference molecules versus patient’ samples (serum; plasma). In our search for non-invasive biomarkers, we hypothesized that patient’ samples (serum; plasma) representing different disease stages should induce different levels of cell-injury according to the clinical classification of the patients.

For example, NASH (F1) patients versus NASH (F4) patients should reflect different levels of injury for items such as lipid uptake, inflammation, oxidative stress and apoptosis. We demonstrated that cell-injury sensing assays using different cell models were able to stratify NASH patient’ samples according to their histological clinical classification. Within this approach , we further hypothesized that circulating  markers should be at the basis of the induction of cel injury and that levels (or changes) to the circulating markers reflect the different disease stages.

For further information on our cell-injury sensing assays, please refer to the Documents Centre of this page.